androgen synthesis inhibitorの例文

例文

1. The androgen synthesis inhibitors aminoglutethimide and ketoconazole were first marketed in 1960 and 1977, respectively, and the newer drug abiraterone acetate was introduced in 2011.
2. The earlier androgen synthesis inhibitors aminoglutethimide and ketoconazole have only limitedly been used in the treatment of prostate cancer due to toxicity concerns and have been replaced by abiraterone acetate.
3. An example is the steroidal antiandrogen cyproterone acetate, which is both a potent AR antagonist and a potent progestogen and hence antigonadotropin, as well as a weak androgen synthesis inhibitor.
4. The most common methods of androgen deprivation therapy currently employed to treat prostate cancer are castration ( with a GnRH analogue or orchiectomy ), non-steroidal antiandrogens, and the androgen synthesis inhibitor abiraterone acetate.
5. Although the term " antiandrogen " is generally used to refer specifically to AR antagonists, it may also be used to describe " functional " antiandrogens like androgen synthesis inhibitors and antigonadotropins, including even estrogens and progestogens.